Neuropeptide degrading enzymes in normal and inflamed human synovium.


Regulatory peptides, including neuropeptides, are metabolized by membrane-bound peptidases. We have localized the membrane peptidases angiotensin-converting enzyme (ACE), dipeptidyl peptidase IV (DPPIV), and aminopeptidase M (APM) in normal and inflamed human synovium by immunohistochemistry and enzyme histochemistry. ACE was localized to endothelial cells… (More)


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