Neuropeptide degradation produces functional inactivation in the crustacean nervous system.

  title={Neuropeptide degradation produces functional inactivation in the crustacean nervous system.},
  author={Melissa J. Coleman and P H Konstant and Brian S. Rothman and Michael P. Nusbaum},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={14 10},
The pentapeptide proctolin (Proct.; Arg-Tyr-Leu-Pro-Thr) is a modulatory transmitter found throughout the crustacean nervous system. No information is available in this system, however, as to how the actions of this peptide are terminated. To study this issue in the crab Cancer borealis, we incubated exogenous proctolin (10(-5) M) with either the thoracic ganglion (TG) or with conditioned saline (CS) that had been preincubated with the TG. We removed aliquots at standard time points for… CONTINUE READING


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