Neuropeptide Y suppresses absence seizures in a genetic rat model primarily through effects on Y receptors.

@article{Morris2007NeuropeptideYS,
  title={Neuropeptide Y suppresses absence seizures in a genetic rat model primarily through effects on Y receptors.},
  author={Margaret Morris and Emma Gannan and Leanne M Stroud and Annette G Beck-Sickinger and Terence J. O'Brien},
  journal={The European journal of neuroscience},
  year={2007},
  volume={25 4},
  pages={1136-43}
}
Neuropeptide Y (NPY) potently suppresses absence seizures in a model of genetic generalized epilepsy, genetic absence epilepsy rats of Strasbourg (GAERS). Here we investigated the Y-receptor subtype(s) on which NPY exerts this anti-absence effect. A dual in vivo approach was used: the cumulative duration of seizures was quantified in adult male GAERS in 90-min electroencephalogram recordings following intracerebroventricular (i.c.v.) injection of: (i) subtype-selective agonists of Y1… CONTINUE READING

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