Neuropeptide Y release in the rat spinal cord measured with Y1 receptor internalization is increased after nerve injury

  title={Neuropeptide Y release in the rat spinal cord measured with Y1 receptor internalization is increased after nerve injury},
  author={Juan Carlos Marviz{\'o}n and Wenling Chen and Weisi Fu and Bradley K. Taylor},

Neurokinin 1 receptor activation in the rat spinal cord maintains latent sensitization, a model of inflammatory and neuropathic chronic pain

To determine if substance P and its neurokinin 1 receptor (NK1R) mediate the maintenance of latent sensitization, NK1R internalization was measured in lamina I neurons in rats injected in the paw with saline or CFA, and then injected intrathecally with saline and naltrexone.

NPY2R signaling gates spontaneous and mechanical, but not thermal, pain transmission

The results suggest that Y1R could be a therapeutic target that may be exploited for alleviating spontaneous pain without affecting acute pain transmission and highlight the pivotal role of endogenous Y2R in gating mechanical and spontaneous pain transmission.

Neuropeptide Y in itch regulation

A Src family kinase maintains latent sensitization in rats, a model of inflammatory and neuropathic pain

Evidence is presented that a Src family kinase, likely Fyn, maintains latent sensitization induced by inflammation or nerve injury, and inhibiting its maintenance with Srcfamily kinase inhibitors may cure chronic pain.

The Role of NPY in the Regulation of Bone Metabolism

A brief overview of the progress made in this research field in recent times is presented in order to provide reference for further understanding the regulatory mechanism of bone physiology and pathological metabolism.

Role of exercise on visceral adiposity after spinal cord injury: a cardiometabolic risk factor

The current evidence supports regular engagement in exercise to reduce VAT mass and the adverse effects on cardiometabolic health in persons with SCI, and will likely facilitate the development of rehabilitation protocols that target VAT reduction in personswith SCI.



Neurokinin 1 Receptor Internalization in Spinal Cord Slices Induced by Dorsal Root Stimulation Is Mediated by NMDA Receptors

The NK1R antagonist L-703,606 abolished the internalization produced by 100 Hz stimulation or NMDA, and the release of SP in the dorsal horn appears to be controlled by NMDA receptors.

Facilitation of neuropathic pain by the NPY Y1 receptor-expressing subpopulation of excitatory interneurons in the dorsal horn

It is concluded that Y1R-expressing excitatory dorsal horn interneurons facilitate neuropathic pain hypersensitivity, and this neuronal population remains sensitive to intrathecal NPY after nerve injury.

NPY Y1 Receptors Are Present in Axonal Processes of DRG Neurons

Results strongly suggest centrifugal transport of Y1Rs in DRG neurons, mainly to the peripheral sensory branches, and a recent study on Y1R null mice provides evidence for involvement of prejunctional Y 1Rs in peripheral sensory functions.

Regulation of Neuropeptide Y Release by Neuropeptide Y Receptor Ligands and Calcium Channel Antagonists in Hypothalamic Slices

It is demonstrated that NPY release from hypothalamic slices is calcium‐dependent, involving N‐, P‐, and Q‐type calcium channels, and inhibited by Y2 agonists and rPP/hPP, suggesting that Y2 and Y4 receptors may act as autoreceptors on NPY‐containing nerve terminals.

Expression of neuropeptide Y and neuropeptide Y (Y1) receptor mRNA in rat spinal cord and dorsal root ganglia following peripheral tissue inflammation

The distinct upregulation of NPY and NPY (Y1) receptor in response to peripheral inflammation suggests an involvement ofNPY in the response to inflammation and in nociception.