Neuropeptide Y receptor genes are associated with alcohol dependence, alcohol withdrawal phenotypes, and cocaine dependence.

@article{Wetherill2008NeuropeptideYR,
  title={Neuropeptide Y receptor genes are associated with alcohol dependence, alcohol withdrawal phenotypes, and cocaine dependence.},
  author={Leah Wetherill and Marc A Schuckit and Victor M. Hesselbrock and Xiaoling Xuei and Tiebing Liang and Danielle M Dick and John R Kramer and JohnI. Nurnberger and Jay A. Tischfield and Bernice Porjesz and Howard J. Edenberg and Tatiana Foroud},
  journal={Alcoholism, clinical and experimental research},
  year={2008},
  volume={32 12},
  pages={
          2031-40
        }
}
BACKGROUND Several lines of evidence in both human and animal studies suggest that variation in neuropeptide Y (NPY) or its receptor genes (NPY1R, NPY2R and NPY5R) is associated with alcohol dependence as well as alcohol withdrawal symptoms. Additional studies suggest that cocaine may affect NPY expression. METHODS A total of 39 single nucleotide polymorphisms (SNPs) were genotyped across NPY and its 3 receptor genes in a sample of 1,923 subjects from 219 multiplex alcoholic families of… CONTINUE READING
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