Neuropeptide Y receptor agonists: multiple effects on spontaneous activity in the paraventricular hypothalamus.

@article{Aramakis1996NeuropeptideYR,
  title={Neuropeptide Y receptor agonists: multiple effects on spontaneous activity in the paraventricular hypothalamus.},
  author={V. Bessie Aramakis and B. Glenn Stanley and John H. Ashe},
  journal={Peptides},
  year={1996},
  volume={17 8},
  pages={1349-57}
}
In vitro rat hypothalamic slices were used to examine the ability of neuropeptide Y (NPY), and the putative Y1 and Y2 receptor agonists [Pro34]NPY and [C2]NPY, to modify spontaneous single-neuron discharge in the paraventricular nucleus (PVN). NPY and [Pro34]NPY, at high concentrations (1500 nM), decreased discharge rates. At intermediate concentrations (150 nM) these peptides produced multiple effects, including increases, decreases, and biphasic changes. At lower concentrations (0.15-15 nM… CONTINUE READING