Neuropeptide Y potentiates noradrenaline-evoked vasoconstriction: mode of action.

  title={Neuropeptide Y potentiates noradrenaline-evoked vasoconstriction: mode of action.},
  author={Claes Wahlestedt and Lars Edvinsson and Eva Ekblad and Rolf H{\aa}kanson},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={234 3},
Neuropeptide Y (NPY), which co-exists with noradrenaline (NA) in postganglionic sympathetic nerves, was able to potentiate NA-evoked constriction in certain isolated rabbit blood vessels. The phenomenon was observed in the femoral, the gastroepiploic and the pulmonary arteries but not in the femoral or the gastroepiploic veins or in the aorta. Thus, NPY potentiated NA-evoked vasoconstriction predominantly in muscular arteries with alpha-1 adrenoceptors. NPY-related peptides, such as peptide YY… CONTINUE READING


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