Neuropeptide Y opposes alcohol effects on gamma-aminobutyric acid release in amygdala and blocks the transition to alcohol dependence.

@article{Gilpin2011NeuropeptideYO,
  title={Neuropeptide Y opposes alcohol effects on gamma-aminobutyric acid release in amygdala and blocks the transition to alcohol dependence.},
  author={Nicholas W Gilpin and Kaushik Misra and Melissa Ann Herman and Maureen T. Cruz and George F. Koob and Marisa Roberto},
  journal={Biological psychiatry},
  year={2011},
  volume={69 11},
  pages={1091-9}
}
BACKGROUND During the transition to alcohol and drug addiction, neuromodulator systems in the extended amygdala are recruited to mediate aspects of withdrawal and relapse via convergence on inhibitory gamma-aminobutyric acid (GABA) neurons in central amygdala (CeA). METHODS This study investigated the role of neuropeptide Y (NPY) in excessive alcohol drinking by making rats dependent on alcohol via alcohol vapor inhalation. This study also utilized intracellular and whole-cell recording… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 36 extracted citations

Role of amygdala in drug memory.

Neurobiology of learning and memory • 2013
View 5 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…