Corpus ID: 42922683

Neuropeptide Y inhibits the nicotine-mediated release of catecholamines from bovine adrenal chromaffin cells.

@article{Higuchi1988NeuropeptideYI,
  title={Neuropeptide Y inhibits the nicotine-mediated release of catecholamines from bovine adrenal chromaffin cells.},
  author={H. Higuchi and E. Costa and H. Y. Yang},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1988},
  volume={244 2},
  pages={
          468-74
        }
}

H. Higuchi, E. Costa, H. Y. Yang

Published 1988

Chemistry, Medicine

The Journal of pharmacology and experimental therapeutics

The possible role of neuropeptide Y (NPY) in catecholamine secretion was studied by using bovine adrenal chromaffin cells. NPY produced a concentration-dependent inhibition of nicotine-stimulated norepinephrine and epinephrine release from bovine chromaffin cells with IC50 (concentration of NPY which inhibits 50% of maximum release of catecholamines) values of 1.8 x 10(-9) M and 1.7 x 10(-9) M, respectively. Catecholamine release induced by 56 mM KCl was not inhibited by NPY at these… CONTINUE READING

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