Neuropeptide Y-induced effects on hypothalamic corticotropin-releasing factor content and release are dependent on noradrenergic/adrenergic neurotransmission

@article{Haas1989NeuropeptideYE,
  title={Neuropeptide Y-induced effects on hypothalamic corticotropin-releasing factor content and release are dependent on noradrenergic/adrenergic neurotransmission},
  author={Daniel A. Haas and Susan R. George},
  journal={Brain Research},
  year={1989},
  volume={498},
  pages={333-338}
}
Neuropeptide Y (NPY) administration increases both hypothalamic corticotropin-releasing factor-like immunoreactivity (CRF-ir) and plasma adrenocorticotropin (ACTH). The dependence of these effects on noradrenaline and adrenaline was investigated by selectively depleting these neurotransmitters with 6-hydroxydopamine (6-OHDA) prior to administration of NPY. This combined treatment decreased hypothalamic CRF-ir (P less than 0.025), an effect isolated to the median eminence (P less than 0.025… Expand
Neuropeptide Y increases the corticotropin-releasing factor messenger ribonucleic acid level in the rat hypothalamus.
TLDR
Central administration of NPY increases the CRF mRNA levels in the hypothalamus and the probable CRF release, which increases the proopiomelanocortin mRNA levels and ACTH secretion in the anterior pituitary, indicating that NPY seems to play a physiological role in the regulation of the release and synthesis of CRF in theothalamus. Expand
NPY Y1 receptors exert opposite effects on corticotropin releasing factor and noradrenaline overflow from the rat hypothalamus in vitro
TLDR
In vitro superfusion techniques were established and it is suggested that NPY, working through a Y1 receptor, has dual and opposing effects on CRF and noradrenaline overflow in vitro. Expand
Effect of dopaminergic and alpha-adrenergic modulation on corticotropin-releasing factor immunoreactivity in rat hypothalamus.
  • D. Haas, S. George
  • Chemistry, Medicine
  • Canadian journal of physiology and pharmacology
  • 1988
TLDR
Results show a reduction in CRF-ir subsequent to either bromocriptine administration, generalized monoamine depletion, alpha 2-stimulation, or selective noradrenaline-adrenalin depletion, presumably by inhibition of CRF release from the median eminence. Expand
Inhibitory interactions between α2-adrenergic and opoid but not NPY mechanisms controlling the CRF-ACTH axis in the rat
TLDR
Data suggest that, in addition to a stimulatory control exerted by postsynapticalpha 2 receptors directly on CRF neurons, other alpha 2 receptors participate, exclusively under the stress conditions above, in a tonic inhibitory control, indirectly mediated to the HPA axis across a stimulatories opioid, but not NPY regulatory component. Expand
Neuroendocrine Actions Of Neuropeptide Y
TLDR
When considered together with the critical orexigenic effects of NPY, it is evident that the arcuate NPY system is important in integrating a variety of physiological, neuroendocrine and behavioral responses to conditions of nutritional inadequacy. Expand
Neuropeptide Y in the paraventricular nucleus of the hypothalamus stimulates colonic transit by peripheral cholinergic and central CRF pathways
  • Mönnikes, Tebbe, Bauer, Grote, Arnold
  • Chemistry, Medicine
  • Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
  • 2000
TLDR
The PVN is more sensitive to agonists acting on the Y1‐ than on theY2‐receptor to mediate stimulation of propulsive colonic motility, and the effect of NPY in the PVN on colonic motor function depends on central CRF and peripheral cholinergic pathways. Expand
Corticotropin-releasing factor and neuropeptide Y mRNA levels are modified by glucocorticoids in rainbow trout, Oncorhynchus mykiss.
TLDR
The results implicate cortisol as a modulator of CRF and NPY mRNA levels in the preoptic area of the trout brain, but that cortisol is only one such regulating mechanism. Expand
Neuroendocrine stress but not feeding responses to centrally administered neuropeptide Y are suppressed in pregnant rats.
TLDR
Neuroendocrine stress responses to central NPY are absent in late pregnancy, whereas ingestive behavioral responses are intact, which may explain the similarly attenuated HPA response to centrally administered orexin-A and will favor anabolic adaptations in pregnancy. Expand
The corticotropin-release inhibitory factor hypothesis: a review of the evidence for the existence of inhibitory as well as stimulatory hypophysiotropic regulation of adrenocorticotropin secretion and biosynthesis.
TLDR
This work has shown that suppression of hypothalamo-pituitary disconnection in adult and fetal sheep and the role of the posterior pituitary in the regulation of corticotropic function contributes to the down-regulation of ACTH release inhibitory activity. Expand
Nicotine activates NPY and catecholaminergic neurons in brainstem regions involved in ACTH secretion
TLDR
Nicotine significantly increased c-Fos expression in a dose-dependent manner in the brainstem regions examined, and NPY projections from the NTS are likely to contribute to nicotine-stimulated ACTH secretion, in addition to the previously described catecholaminergic neurons. Expand
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References

SHOWING 1-10 OF 35 REFERENCES
Neuropeptide Y administration acutely increases hypothalamic corticotropin-releasing factor immunoreactivity: lack of effect in other rat brain regions.
TLDR
Data show that NPY can alter the content of hypothalamic CRF and may play a role in its regulation, and plasma adrenocorticotropin levels were found to increase following NPY treatment. Expand
Effect of dopaminergic and alpha-adrenergic modulation on corticotropin-releasing factor immunoreactivity in rat hypothalamus.
  • D. Haas, S. George
  • Chemistry, Medicine
  • Canadian journal of physiology and pharmacology
  • 1988
TLDR
Results show a reduction in CRF-ir subsequent to either bromocriptine administration, generalized monoamine depletion, alpha 2-stimulation, or selective noradrenaline-adrenalin depletion, presumably by inhibition of CRF release from the median eminence. Expand
Further studies on the effects of central administration of neuropeptide Y on neuroendocrine function in the male rat: relationship to hypothalamic catecholamines
TLDR
It is suggested that the NPY induced changes in DA utilization in the tuberoinfundibular DA neurons may contribute to theNPY induced changed in PRL and TSH secretion. Expand
Facilitation of immunoreactive corticotropin-releasing factor secretion into the hypophysial-portal circulation after activation of catecholaminergic pathways or central norepinephrine injection.
TLDR
Observations provide strong evidence in favor of a predominantly stimulatory action of NE (and possibly epinephrine) at the hypothalamic level to evoke secretion of CRF and thus to activate the pituitary-adrenal axis. Expand
The corticotropin-releasing factor release in rat hypophysial portal blood is mediated by brain catecholamines.
TLDR
The results suggest that central catecholamines exert a direct stimulatory control on the CRF release and play a major role in stress-induced ACTH secretion. Expand
Neuropeptide Y (NPY) in the area of the hypothalamic paraventricular nucleus activates the pituitary-adrenocortical axis in the rat
TLDR
An activating effect of NPY is demonstrated on the pituitary-adrenocortical axis both in conscious and anaesthetized rats which may reflect the anatomical relationship between NPY fibres and CRF neurones in the PVN. Expand
The effect of 6-hydroxydopamine, reserpine and cold stress on the neuropeptide Y content of the rat central nervous system
TLDR
The results suggest that the bulk of neuropeptide Y in the rat brain and spinal cord may not be stored in catecholaminergic nerve terminals. Expand
Further evidence for a central stimulatory action of catecholamines on adrenocorticotropin release in the rat.
TLDR
A stress-like stimulatory dose response was noted after both adrenaline and noradrenaline infusions, with a half-maximal effect at concentrations of about 0.6 nmol and a maximal effect at 2.7 nmol or more, at maximally effective doses, adrenaline was significantly more active than norad Renaline. Expand
Time course study on the effect of reserpine on hypothalamic immunoreactive CRF levels in rats
TLDR
A time course study on the changes of rat hypothalamic corticotropin-releasing factor levels and ACTH levels in plasma, pituitary and hypothalamus after an acute treatment with reserpine suggested that noradrenergic pathways may be involved in the inhibitory mechanism of CRF release. Expand
Noradrenaline and neuropeptide Y innervation of the rat hypothalamus are differentially affected by 6-hydroxydopamine
TLDR
Results indicate that the hypothalamic NPY innervation arises in large part from intrinsic NPY-producing neurons rather than from medullary neurons in which NA and NPY coexist. Expand
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