Neuropeptide Y increases the corticotropin-releasing factor messenger ribonucleic acid level in the rat hypothalamus.

@article{Suda1993NeuropeptideYI,
  title={Neuropeptide Y increases the corticotropin-releasing factor messenger ribonucleic acid level in the rat hypothalamus.},
  author={Takane Suda and Fumiko Tozawa and I Iwai and Yoshihiro Sato and Toru Sumitomo and Yasushi Nakano and Mitsuru Yamada and Hiroshi Demura},
  journal={Brain research. Molecular brain research},
  year={1993},
  volume={18 4},
  pages={311-5}
}
Neuropeptide Y (NPY) has a stimulatory effect on adrenocorticotropin (ACTH) and corticotropin-releasing factor (CRF) release. In the present study, to investigate the effect of NPY on CRF synthesis, the effect of centrally administered NPY on CRF messenger RNA (mRNA) levels in rat hypothalamus was examined under pentobarbital anesthesia. The administration of 0.01, 0.1 and 1 nmol of NPY into the lateral ventricle dose-dependently Increased the plasma ACTH levels, as well as the levels of… CONTINUE READING

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