Neuropeptide Y functions as a neuroproliferative factor

@article{Hansel2001NeuropeptideYF,
  title={Neuropeptide Y functions as a neuroproliferative factor},
  author={Donna E. Hansel and Betty A. Eipper and Gabriele V. Ronnett},
  journal={Nature},
  year={2001},
  volume={410},
  pages={940-944}
}
Neuropeptide Y (NPY) has a number of functions in mammalian physiology. Here we identify a role for NPY in promoting proliferation of postnatal neuronal precursor cells. NPY is synthesized in the postnatal olfactory epithelium by sustentacular cells, previously proposed to function only in structural support. Mice with a targeted deletion of NPY contain half as many dividing olfactory neuronal precursor cells as do controls. Furthermore, NPY-deficient mice develop significantly fewer olfactory… Expand
Intracellular Nitric Oxide Mediates Neuroproliferative Effect of Neuropeptide Y on Postnatal Hippocampal Precursor Cells*
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It is shown that NPY-mediated intracellular NO signaling results in an increase in neuroproliferation, and the importance of the NO-cGMP-PKG signaling pathway in ERK1/2 activation was confirmed using Western blotting. Expand
Neuropeptide Y stimulates proliferation, migration and differentiation of neural precursors from the subventricular zone in adult mice
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It is demonstrated that intracerebroventricular injection of NPY stimulates proliferation of neural precursors in the mice subventricular zone (SVZ), one the most neurogenic areas of the brain. Expand
Functional expression of neuropeptide Y receptors in human neuroblastoma cells
TLDR
Results suggest that endogenously expressed NPY may control proliferation of these cells through a paracrine/autocrine mechanism. Expand
Neuropeptide Y Promotes Neurogenesis in Murine Subventricular Zone
TLDR
NPY, as a promoter of SVZ neurogenesis, is a crucial factor for future development of cell‐based brain therapy and may be useful for the stimulation of SVz dynamic in brain repair purposes. Expand
Cellular targets for neuropeptide Y-mediated control of adult neurogenesis
TLDR
Current data on NPY signaling in the different cellular components of the neurogenic niche is summarized and discussed in order to elucidate the complexity of the mechanisms underlying the modulatory properties of this peptide. Expand
Exogenous neuropeptide Y promotes in vivo hippocampal neurogenesis
TLDR
It is shown that intracerebroventricular administration of NPY increases DG cell proliferation and promotes neuronal differentiation in C57BL/6 adult mice, demonstrating that NPY regulates in vivo hippocampal neurogenesis. Expand
Neuropeptides as growth factors for normal and cancerous cells
  • E. Rozengurt
  • Medicine, Biology
  • Trends in Endocrinology & Metabolism
  • 2002
TLDR
A major task for the future will be to identify all the contributing molecules, define their functional importance and elucidate the spatiotemporal relationships of this complicated signaling network. Expand
Neuropeptide Y stimulates retinal neural cell proliferation – involvement of nitric oxide
TLDR
NPY stimulates retinal neural cell proliferation, and this effect is mediated through nitric oxide–cyclic GMP and ERK 1/2 pathways. Expand
Neuropeptide Y increases differentiation of human olfactory receptor neurons through the Y1 receptor
TLDR
NPY not only increases expressions of protein markers of human olfactory neuronal progenitor cells, but also promotes differentiation of ORN and enhances formation of components of olf factory-specific signal transduction pathway through Y1 receptors. Expand
Emerging novel roles of neuropeptide Y in the retina: From neuromodulation to neuroprotection
TLDR
Although the physiological roles of NPY in the retina have not been completely elucidated, its early expression strongly suggests that NPY may be involved in the development of retinal circuitry, and its receptors might be viewed as potentially novel therapeutic targets. Expand
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References

SHOWING 1-10 OF 30 REFERENCES
Intracellular signaling leads to the hypertrophic effect of neuropeptide Y.
TLDR
NPY stimulates protein synthesis in adult cardiomyocytes through activation of PTx-sensitive G proteins and PI 3-kinase and it induces the fetal-type CK-BB via activation of PKC and MAP kinase. Expand
Neuropeptide-Y stimulation of extracellular signal-regulated kinases in human erythroleukemia cells.
TLDR
It is concluded that NPY does not activate phospholipase D, PKC, jun N-terminal kinase, or p38 MAPK in HEL cells, however, NPY activates ERK by a pathway involving Y(1) receptors, pertussis toxin-sensitive G proteins, and phosphatidylinositol-3-kinase, whereas PKC may not be involved. Expand
Neuropeptide Y (NPY) potentiates phenylephrine-induced mitogen-activated protein kinase activation in primary cardiomyocytes via NPY Y5 receptors.
TLDR
Results suggest that NPY, via G(i) protein-coupled NPY Y5 receptors, could participate in the development of cardiac hypertrophy during chronic sympathetic stimulation by potentiating alpha-adrenergic signals. Expand
Neuropeptide Y: localization in the central nervous system and neuroendocrine functions
Summary— Neuropeptide Y (NPY) is a 36‐amino acid peptide first isolated and characterized from porcine brain extracts. A number of immunocytochemical investigations have been conducted to determineExpand
Neuropeptide Y Family of Hormones: Receptor Subtypes and Antagonists
TLDR
The existence of numerous atypical activities provide strong evidence for the occurrence of additional NPY receptor subtypes, and the cloned Y-5 receptor has been suggested to be the long awaited Y-1-like receptor involved in feeding. Expand
Neuropeptide Y stimulates DNA synthesis in vascular smooth muscle cells
TLDR
NPY may induce Ca2+ mobilization and stimulation of DNA synthesis in vascular smooth muscle cells via Y1 receptors whose signal transduction system involves pertussis toxin-sensitive GTP-binding protein(s). Expand
Neuropeptide Y (NPY) enhances proliferation of human colonic lamina propria lymphocytes
TLDR
It is demonstrated that NPY enhances human colonic LPL proliferation and that this effect is partially IL1-beta dependent, and the data suggest thatNPY's effect may be mediated via polyamine biosynthesis. Expand
The neuropeptide Y/peptide YY Y1 receptor is coupled to MAP kinase via PKC and Ras in CHO cells.
TLDR
Data suggest a novel mechanism for Y1 receptor coupling to MAPK, which is at once pertussis toxin-sensitive as well as PKC- and Ras-dependent, and also suggests involvement of Gi or G(o) proteins. Expand
Knock-Out Mice Reveal a Critical Antiepileptic Role for Neuropeptide Y
TLDR
A critical role is suggested for endogenous NPY in seizure control in mutant mice lacking this peptide, and intracerebroventricular NPY infusion, before KA administration, prevented death in NPY-deficient mice. Expand
Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y
TLDR
It is reported here that mice deficient for NPY have normal food intake and body weight, and become hyperphagic following food deprivation, and mutants are more susceptible to seizures induced by a GABA (γ-aminobutyric acid) antagonist when treated with recombinant leptin. Expand
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