Neuropeptide Y functions as a facilitator of GDNF-induced budding of the Wolffian duct.

@article{Choi2009NeuropeptideYF,
  title={Neuropeptide Y functions as a facilitator of GDNF-induced budding of the Wolffian duct.},
  author={Yohan Choi and James B. Tee and Thomas F. Gallegos and Mita M Shah and Hideto Oishi and Hiroyuki Sakurai and Shinji Kitamura and Wei Wu and Kevin T Bush and Sanjay K. Nigam},
  journal={Development},
  year={2009},
  volume={136 24},
  pages={4213-24}
}
Ureteric bud (UB) emergence from the Wolffian duct (WD), the initiating step in metanephric kidney morphogenesis, is dependent on GDNF; however, GDNF by itself is generally insufficient to induce robust budding of the isolated WD in culture. Thus, additional factors, presumably peptides or polypeptide growth factors, might be involved. Microarray data from in vivo budding and non-budding conditions were analyzed using non-negative matrix factorization followed by gene ontology filtering and… CONTINUE READING