Neuropeptide Y effects on vasorelaxation and intestinal contraction in the Atlantic cod Gadus morhua.

  title={Neuropeptide Y effects on vasorelaxation and intestinal contraction in the Atlantic cod Gadus morhua.},
  author={F. Shahbazi and S. Holmgren and D. Larhammar and J{\"o}rgen Jensen},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  volume={282 5},
  • F. Shahbazi, S. Holmgren, +1 author Jörgen Jensen
  • Published 2002
  • Biology, Medicine
  • American journal of physiology. Regulatory, integrative and comparative physiology
  • Neuropeptide Y (NPY) has prominent cardiovascular effects in mammals and sharks, but no such effect has previously been demonstrated in any teleost fish. In the Atlantic cod, we found that cod NPY (10(-10)-10(-6) M) relaxed celiac arteries precontracted with epinephrine, and weak contractions were elicited in intestinal ring preparations. A few NPY-immunoreactive nerve fibers were present along small gut arteries. The results suggest that cod NPY produces vasorelaxation both by a direct action… CONTINUE READING
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