Neuropeptide Y can rescue neurons from cell death following the application of an excitotoxic insult with kainate in rat organotypic hippocampal slice cultures.

@article{Xapelli2007NeuropeptideYC,
  title={Neuropeptide Y can rescue neurons from cell death following the application of an excitotoxic insult with kainate in rat organotypic hippocampal slice cultures.},
  author={Sara Xapelli and Ana Paula Silva and Raquel L. Ferreira and Jo{\~a}o Oliveira Malva},
  journal={Peptides},
  year={2007},
  volume={28 2},
  pages={288-94}
}
In the present work we investigated the neuroprotective role of neuropeptide Y (NPY) after an excitotoxic insult in rat organotypic hippocampal slice cultures. Exposure of 2 week-old rat hippocampal slice cultures to 12muM kainate (KA) for 24h induced neuronal death in dentate gyrus (DG) granular cell layer, CA1 and CA3 pyramidal cell layers, as quantified… CONTINUE READING