Neuropeptide Y and its role in CNS disease and repair

@article{Decressac2012NeuropeptideYA,
  title={Neuropeptide Y and its role in CNS disease and repair},
  author={Mickael Decressac and Roger A. Barker},
  journal={Experimental Neurology},
  year={2012},
  volume={238},
  pages={265-272}
}
Neuropeptide Y (NPY) is widely expressed throughout the CNS and exerts a number of important physiological functions as well as playing a role in pathological conditions such as obesity, anxiety, epilepsy, chronic pain and neurodegenerative disorders. In this review, we highlight some of the recent advances in our understanding of NPY biology and how this may help explain not only its role in health and disease, but also its possible use therapeutically. 
Roles of Neuropeptide Y in Neurodegenerative and Neuroimmune Diseases
TLDR
This review will focus on the roles of NPY in the pathological mechanisms of neurodegenerative and neuroimmune diseases, highlighting NPY as a potential therapeutic target in these diseases. Expand
The effect of neuropeptide Y on cell survival and neurotrophin expression in in-vitro models of Alzheimer's disease.
TLDR
The recent in-vitro evidence for the involvement of neurotrophin nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) in the neuroprotective effect elicited by NPY is recapitulated, and a putative mechanism based on NPY-induced inhibition of voltage-dependent Ca(2+) influx in pre- and post-synaptic neurons is proposed. Expand
Physiological and Therapeutic Roles of Neuropeptide Y on Biological Functions.
  • P. Shende, D. Desai
  • Medicine, Chemistry
  • Advances in experimental medicine and biology
  • 2019
TLDR
NPY plays a role in dietary consumption via various factors like signaling the CNS for a prerequisite of energy in hypothalamus by mediating appetite and shows orexigenic effect and its role in food intake, sexual behavior, blood pressure, etc. by inhibiting calcium and activating potassium channels. Expand
Cellular targets for neuropeptide Y-mediated control of adult neurogenesis
TLDR
Current data on NPY signaling in the different cellular components of the neurogenic niche is summarized and discussed in order to elucidate the complexity of the mechanisms underlying the modulatory properties of this peptide. Expand
The Role of Neuropeptide Y in the Nucleus Accumbens
  • Masaki Tanaka, Shunji Yamada, Yoshihisa Watanabe
  • Medicine
  • International journal of molecular sciences
  • 2021
TLDR
Altering in NPY expression under certain conditions through intra-NAc injections of NPY or receptor agonists/antagonists revealed NPY to be involved in the characteristic functions of the NAc, such as alcohol intake and drug addiction. Expand
Altered expression of neuropeptide Y, Y1 and Y2 receptors, but not Y5 receptor, within hippocampus and temporal lobe cortex of tremor rats
TLDR
The results showed the altered expression of NPY, Y1R and Y2R but not Y5R in hippocampus and temporal lobe cortex of TRM brain may be associated with the generation of epileptiform activity and provide a candidate target for treatment of genetic epilepsy. Expand
Neuropeptide Y: A stressful review
TLDR
There is a negative correlation between stress-induced behavioural disruption and cerebral NPY expression in animal models of post-traumatic stress disorder, which indicates a role in stress resilience, the ability to cope with stress. Expand
Defects in the striatal neuropeptide Y system in X-linked dystonia-parkinsonism.
TLDR
A neostriatal defect of the neuropeptide Y system in patients with X- linked dystonia-parkinsonism is indicated, suggesting its possible implication in the mechanism by which a progressive loss of striatal neurons occurs in X-linked dystonian diseases. Expand
Copper Binding Induces Nitration of NPY under Nitrative Stress: Complicating the Role of NPY in Alzheimer's Disease.
TLDR
The hypothesis that copper has a close correlation with NPY and implicates the peptide in AD is supported and may provide a new insight into understanding the pathology and pathogenesis of AD. Expand
The Neurogenic Effects of Exogenous Neuropeptide Y: Early Molecular Events and Long-Lasting Effects in the Hippocampus of Trimethyltin-Treated Rats
TLDR
The data indicate that the neurogenic effect of NPY administration during TMT-induced neurodegeneration involves early Shh pathway activation and results in a functional integration of newly-generated neurons into the local circuit. Expand
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TLDR
NPY is involved in the regulatory loops that control food intake in the hypothalamus and appears also to be important for regulating the activity of neuroendocrine axes under poor metabolic conditions, which makes it an attractive target for the potential treatment of human diseases, such as obesity, metabolic disorders, hypertension and heart failure. Expand
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TLDR
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TLDR
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TLDR
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TLDR
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