Neuropeptide Y and Leptin Sensitivity is Dependent on Diet Composition

@article{Heuvel2014NeuropeptideYA,
  title={Neuropeptide Y and Leptin Sensitivity is Dependent on Diet Composition},
  author={J. K. Vd Heuvel and Leslie Eggels and Andrea J. Rozen and Mieneke C. M. Luijendijk and Eric Fliers and Andries Kalsbeek and Roger A. H. Adan and Susanne E. la Fleur},
  journal={Journal of Neuroendocrinology},
  year={2014},
  volume={26}
}
Rats on different free‐choice (fc) diets for 1 week of either chow, saturated fat and liquid sugar (fcHFHS), chow and saturated fat (fcHF), or chow and liquid sugar (fcHS) have differential levels of neuropeptide Y (NPY) mRNA in the arcuate nucleus. Because these differences were not explained by plasma leptin levels but did predict subsequent feeding behaviour, in the present study, we first examined whether leptin sensitivity could explain these differences. Second, we focused on the role of… 
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Effects of Neuropeptide Y administration into the lateral hypothalamus on intake of free-choice high-fat high-sucrose diet components of the male Wistar rat
TLDR
The data demonstrate that the effects of intra-LHA NPY on caloric intake differ depending on the consumption of a fat or sugar component, or both, in a free-choice diet and indicate that baseline preference for the fat diet component modulates the effects for intra-Npy expression in the arcuate nucleus in fcHFHS-fed rats.
Neuropeptide Y Signaling in the Lateral Hypothalamus Modulates Diet Component Selection and is Dysregulated in a Model of Diet-Induced Obesity
Effects of neurosecretory protein GL on food intake and fat accumulation under different dietary nutrient compositions in rats.
TLDR
The data suggest that the effects of NPGL on feeding behavior, body mass gain, and fat accumulation depend on nutrient type, and among them, sucrose in diets seems to contribute to fat accumulation elicited by N PGL.
Inhibitory Effect of the Melanocortin Receptor Agonist Melanotan-II (MTII) on Feeding Depends on Dietary Fat Content and not Obesity in Rats on Free-Choice Diets
TLDR
Rats on the fc HF diet show stronger food intake inhibition to the melanocortin receptor agonist MTII than rats on the CHOW, fcHS, and fcHFHS diet, which is independent of caloric intake and body weight gain.
The effects of overnight nutrient intake on hypothalamic inflammation in a free-choice diet-induced obesity rat model
Is leptin resistance the cause or the consequence of diet-induced obesity?
TLDR
A pre-existing reduction in leptin sensitivity determines the susceptibility to develop excessive DIO after fcHFHS diet exposure, and rats with a pre- existing reduction inptin sensitivity develop excessiveDIO without eating more calories or altering their leptin sensitivity.
Effects of dietary macronutrient composition on exogenous neuropeptide Y’s stimulation of food intake in chicks
Neural pathways controlling homeostatic and hedonic feeding in rats on free-choice diets
TLDR
It is shown that the composition of the diet, and not the fat mass per se, is important for how the brain responds to diet-induced obesity and subsequently regulates feeding behavior, and a novel role of NPY in the brain reward center (nucleus accumbens) is revealed.
Neuropeptide Y Activity in the Nucleus Accumbens Modulates Feeding Behavior and Neuronal Activity
Dietary Macronutrient Composition Affects the Influence of Exogenous Prolactin-Releasing Peptide on Appetite Responses and Hypothalamic Gene Expression in Chickens.
TLDR
The HP diet enhanced the sensitivity of chicks to the food intake-stimulating effects of PrRP, and PrRP in turn increased preference for the HP diet, and dietary macronutrient composition affects nutrient intake and transcriptional regulation in chicks.
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