Neuropeptide Y acts directly in the periphery on fat tissue and mediates stress-induced obesity and metabolic syndrome

@article{Kuo2007NeuropeptideYA,
  title={Neuropeptide Y acts directly in the periphery on fat tissue and mediates stress-induced obesity and metabolic syndrome},
  author={Lydia E. Kuo and Joanna B. Kitlinska and Jason U. Tilan and Lijun Li and Stephen B. Baker and Michael D. Johnson and Edward Wolfgang Lee and Mary Susan Burnett and Stanley Thomas Fricke and Richard Kvetňansk{\'y} and Herbert Herzog and Zofia Zukowska},
  journal={Nature Medicine},
  year={2007},
  volume={13},
  pages={803-811}
}
The relationship between stress and obesity remains elusive. In response to stress, some people lose weight, whereas others gain. Here we report that stress exaggerates diet-induced obesity through a peripheral mechanism in the abdominal white adipose tissue that is mediated by neuropeptide Y (NPY). Stressors such as exposure to cold or aggression lead to the release of NPY from sympathetic nerves, which in turn upregulates NPY and its Y2 receptors (NPY2R) in a glucocorticoid-dependent manner… Expand
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