Neuropeptide Y Y5 receptor antagonism causes faster extinction and attenuates reinstatement in cocaine-induced place preference

@article{Srensen2013NeuropeptideYY,
  title={Neuropeptide Y Y5 receptor antagonism causes faster extinction and attenuates reinstatement in cocaine-induced place preference},
  author={Gunnar S{\o}rensen and Gitta W{\"o}rtwein and Anders Fink-Jensen and David Paul Drucker Woldbye},
  journal={Pharmacology Biochemistry and Behavior},
  year={2013},
  volume={105},
  pages={151-156}
}
Several studies have suggested a role for neuropeptide Y (NPY) in addiction to drugs of abuse, including cocaine. Recently, our group showed a role for the NPY Y5 receptor in the modulation of acute reinforcing effects of cocaine using self-administration and hyperlocomotion paradigms. In the present study, we further explored potential anti-addiction-related effects of Y5 antagonism in another murine model of cocaine addiction-related behavior: conditioned place-preference (CPP). Using this… CONTINUE READING
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