Neuropeptide Y Y2 receptor‐mediated attenuation of neurogenic plasma extravasation acting through pertussis toxin‐sensitive mechanisms

  title={Neuropeptide Y Y2 receptor‐mediated attenuation of neurogenic plasma extravasation acting through pertussis toxin‐sensitive mechanisms},
  author={X J Yu and M. A. Moskowitz},
  journal={British Journal of Pharmacology},
  • X. YuM. A. Moskowitz
  • Published 1 September 1996
  • Biology, Medicine, Chemistry
  • British Journal of Pharmacology
1 The effects of neuropeptide Y (NPY) receptor agonists (administered intravenously) were examined on plasma protein ([125I]‐bovine serum albumin) leakage within dura mater evoked by unilateral trigeminal ganglion stimulation (0.6 mA, 5 ms, 5 Hz, 5 min), capsaicin (1 μmol kg−1, i.v.) or substance P (1 nmol kg−1, i.v.) in anaesthetized Sprague‐Dawley rats. 2 NPY (EC50: 5.6 nmol kg−1) and NPY fragment 13–36 [NPY (13–36)] (ED50: 4.3 nmol kg−1), an NPY Y2 receptor agonist, dose‐dependently… 

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