Neuropeptide Y Y1 and neuropeptide Y Y2 receptors in human cardiovascular tissues

@article{Uddman2002NeuropeptideYY,
  title={Neuropeptide Y Y1 and neuropeptide Y Y2 receptors in human cardiovascular tissues},
  author={Rolf Uddman and Sebastian M{\"o}ller and Torun Nilsson and Susanne Nyström and Jonas Ekstrand and Lars Edvinsson},
  journal={Peptides},
  year={2002},
  volume={23},
  pages={927-934}
}
Neuropeptide Y2 receptor protein is present in peptidergic and nonpeptidergic primary sensory neurons of the mouse
TLDR
It is demonstrated that the NPY Y2R is associated mainly with both peptidergic and nonpeptidergics small, presumably nociceptive, neurons projecting to the superficial layers of the dorsal horn, and support a role for this receptor and NPY in pain mechanisms.
Neuropeptide Y and Cardiovascular Function
TLDR
While it is difficult to judge the precise role of central NPY in cardiovascular regulation, in the brain NPY exerts depressor effects and modulates baroreceptor function, and Neurons containing NPY also participate in central cardiovascular control.
Modulator role of neuropeptide Y in human vascular sympathetic neuroeffector junctions.
TLDR
RT-PCR studies identified the mRNA coding for the Y1 and Y2 receptors in human mammary artery/vein and saphenous vein biopsies, where NPY plays a modulator role of paramount importance following increased sympathetic discharges, such as stress and vascular disease.
Neuropeptide Y and its Y2 Receptor – Potential Targets in Neuroblastoma Therapy
TLDR
Y2R is a promising new target for neuroblastoma therapy affecting both cancer cells and tumor vasculature and exerted an antiangiogenic effect.
Neuropeptide Y Y2 receptor in health and disease
TLDR
Property of the receptor and of Y2 agonists are considered and reviewed in connection to the negative regulation of transmitter release, feeding, mood and social behavior and the possible involvement of the Y2 receptor in diabetes, carcinogenesis and bone formation is reviewed.
Neuropeptide Y Y1 receptor mRNA in rodent brain: Distribution and colocalization with melanocortin‐4 receptor
TLDR
The present study systematically examined the brain distribution of Y1‐R mRNA in rodents by using radioisotopic in situ hybridization histochemistry (ISHH) with a novel sensitive cRNA probe, and demonstrated that hypophysiotropic PVH cells coexpress Y1-R and pro–thyrotropin‐releasing hormone mRNAs in the rat.
Neuropeptide Y2 receptors are involved in enhanced neurogenic vasoconstriction in spontaneously hypertensive rats
TLDR
Both enhanced NPY content and altered neuropeptide Y1 and Y2 receptor activation apparently contribute to the enhanced neurogenic contraction of arteries from SHR.
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References

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TLDR
It is concluded that smooth muscle Y1 receptors are the primary if not exclusive NPY receptors associated with human brain extraparenchymal and intraparen chymal blood vessels, where they most likely mediate cerebral vasoconstriction.
Localization of neuropeptide Y Y1 receptors in cerebral blood vessels.
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TLDR
The results indicate that NPY has a profound effect on small arterioles of the brain acting on Y1-Rs, both on the peripheral and luminal side of the SMCs, however, the source of the endogenous ligand, NPY, remains unclear.
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TLDR
In situ hybridization of mouse brain sections reveals expression of this novel NPY receptor within discrete regions of the hypothalamus including the suprachiasmatic nucleus, anterior hypothalamus, bed nucleus stria terminalis, and the ventromedial nucleus with no localization apparent elsewhere in the brain.
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TLDR
Y2R mRNA levels increase in rat spinal motoneurons after axotomy, and under normal circumstances NPY may act on Y1 and Y2Rs expressed, respectively, in small and large CGRP-positive DRG neurons in the rat.
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TLDR
It is demonstrated that second messenger coupling of the NPY-Y1 receptor is cell type specific, depending on the specific repertoire of G proteins and effector systems present in any cell type.
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TLDR
The isolation of a human Y2 (hhY2) receptor cDNA by expression cloning from a human hippocampal cDNA library is reported, using a 125I-PYY binding assay.
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TLDR
The results suggest that the Y1β receptor is an embryonic and a bone marrow form of the NPY-Y1 receptor, which decreases in the expression during development and differentiation.
Intron-mediated expression of the human neuropeptide Y Y1 receptor
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