Neuropeptide Y Stimulates Proliferation and Migration of Vascular Smooth Muscle Cells from Pregnancy Hypertensive Rats via Y1 and Y5 Receptors

@article{Zhang2015NeuropeptideYS,
  title={Neuropeptide Y Stimulates Proliferation and Migration of Vascular Smooth Muscle Cells from Pregnancy Hypertensive Rats via Y1 and Y5 Receptors},
  author={Ping Zhang and Ying-xin Qi and Qing-Ping Yao and Xiao-Hu Chen and G. Wang and Bao-rong Shen and Y. Han and Li-Zhi Gao and Z. Jiang},
  journal={PLoS ONE},
  year={2015},
  volume={10}
}
  • Ping Zhang, Ying-xin Qi, +6 authors Z. Jiang
  • Published 2015
  • Medicine, Biology
  • PLoS ONE
  • The increased proliferation and migration of vascular smooth muscle cells (VSMCs) play important roles in pathophysiological remodeling of arteries during hypertension in pregnancy. However, the mechanisms involved in this process remain unclear. We hypothesized that Neuropeptide Y (NPY), which is a potent mitogenic peptide, participates in modulating proliferation and migration of VSMCs during hypertension in pregnancy. Using pregnant hypertensive rats, induced by intraperitoneal injection of… CONTINUE READING
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