Neuropeptide Y Pathways in Anxiety-Related Disorders

  title={Neuropeptide Y Pathways in Anxiety-Related Disorders},
  author={Yvan Dumont and Rémi Quirion},
  journal={Biological Psychiatry},
Anxiety reflects a state of cognitive and behavioral preparedness that an organism mobilizes in response to a potential threat. Anxiety can be conceptualized as having two components: state and trait. Trait anxiety refers to an individual’s personality and predisposition for anxiety, whereas state anxiety refers to the emotional response generated by a perceived threat. Traditional research in anxiety in humans and animal models have focused on understanding neurologic deficits in individuals… Expand
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Single prolonged stress PTSD model triggers progressive severity of anxiety, altered gene expression in locus coeruleus and hypothalamus and effected sensitivity to NPY
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NPY‐Y1 coexpressed with NPY‐Y5 receptors modulate anxiety but not mild social stress response in mice
The results suggest that group housing constitutes a mild social stress for the B6129S mouse strain and they confirm that the conditional inactivation of Y1 receptors specifically in Y5 receptor containing neurons increases stress‐related anxiety without affecting endocrine stress responses. Expand
Neuropeptide Y and representation of salience in human nucleus accumbens
These results provide the first evidence in humans linking NPY with salience sensitivity of the NAc, raising the possibility that individual differences in NPY expression moderate the risk for disorders of mesoaccumbal function such as addictions and mood disorders. Expand
Conditional inactivation of Npy1r gene in mice induces behavioural inflexibility and orbitofrontal cortex hyperactivity that are reversed by escitalopram
It is suggested that the inactivation of Y1R in Y5R containing neurons increases pyramidal neuron activity and dysregulates serotoninergic tone in OFC, whereby contributing to reversal learning impairment. Expand
Single stimulation of Y2 receptors in BNSTav facilitates extinction and dampens reinstatement of fear
Local Y2R stimulation in BNSTav promotes fear extinction and stabilizes suppression of reinstated fear through a long-term influence, even without extinction training, which is crucial for extinction-based remote fear suppression. Expand
The Effect of Circumcision on the Mental Health of Children Running Head: Circumcision and Mental Health
To investigate the effects of circumcision on children’s behavioral characteristics, de-pression and anxiety levels. 35 boys, aged between 6-11, who were scheduled to be circumcised were included inExpand
Spatial and temporal immunoreactivity in the rat brain using an affinity purified polyclonal antibody to DNSP-11
DNSP-11 antibody signal was investigated in perfusion fixated Fischer 344 rat brains by immunohistochemistry with a custom, affinity purified polyclonal antibody. The DNSP-11-antibody signal wasExpand
Investigating the molecular mechanisms of learning and memory using Caenorhabditis elegans
How learning and memory can be studied in C. elegans through behavioural paradigms that target distinct sensory modalities is detailed, and mechanisms through which key molecular and cellular pathways are proposed to affect associative and non-associative forms of learning are summarized. Expand


Neuropeptide Y and its Role in Anxiety-related Disorders
Results support the hypothesis that NPY and its receptors may be involved in the regulation of anxiety-related behaviours and provide evidence that this neuropeptide family is an attractive drug development target for these disorders. Expand
Individual differences in the effects of chronic stress on memory: Behavioral and neurochemical correlates of resiliency
Chronic stress has been shown to impair memory, however, the extent to which memory can be impaired is often variable across individuals. Predisposed differences in particular traits, such asExpand
Neuropeptide Y Receptor Gene Expression in the Primate Amygdala Predicts Anxious Temperament and Brain Metabolism
Low mRNA levels of neuropeptide Y receptor 1 and NPY5R but not NPY or NPY2R in the Ce predicted elevated AT, suggesting that enhancement of NPY signaling might reduce the risk to develop psychopathology. Expand
Effects of sex and deletion of neuropeptide Y2 receptors from GABAergic neurons on affective and alcohol drinking behaviors in mice
It is found that females displayed greater basal anxiety, higher levels of ethanol consumption, and faster fear conditioning than males, and that VGAT-Y2R knockout mice exhibited enhanced depressive-like behavior in the forced swim test. Expand
Regulatory functions of limbic Y1 receptors in body weight and anxiety uncovered by conditional knockout and maternal care
Conditional knockout mice in which the inactivation of the Npy1r gene was restricted to excitatory neurons of the forebrain exhibited increased anxiety and reduced body weight, less adipose tissue, and lower serum leptin levels, suggesting that limbic Y1Rs are key targets of maternal care-induced programming of anxiety and energy homeostasis. Expand
Conditional Inactivation of Neuropeptide Y Y1 Receptors Unravels the Role of Y1 and Y5 Receptors Coexpressing Neurons in Anxiety
The results suggest that neuropeptide Y Y1R differentially expressed in the limbic system regulates anxiety and stress responses via distinct neurochemical circuits and provide the first experimental genetic evidence that the Y1Rs coexpressed with the Y5R are involved in retention of spatial memory in male and female mice. Expand
Cell-specific expression of calcineurin immunoreactivity within the rat basolateral amygdala complex and colocalization with the neuropeptide Y Y1 receptor
Anatomical findings provide a model whereby NPY could directly regulate CaN activity in the BLA via activation of the Y1r on CaN-expressing, pyramidal neurons, and support BLA pyramsidal neurons as prime targets for neuronal plasticity associated with the long-term reductions in anxiety-like behavior produced by NPY injections into theBLA. Expand
Nicotine evoked improvement in learning and memory is mediated through NPY Y1 receptors in rat model of Alzheimer's disease
It is suggested that NPY, perhaps acting via NPY Y1 receptors, might interact with the endogenous cholinergic system and play a role in improving the learning and memory processes in the rats with AD-like condition. Expand
Comparative distribution of neuropeptide Y Y1 and Y5 receptors in the rat brain by using immunohistochemistry
Detailed and comparative mapping of Y1 and Y5 receptor subtypes within cell bodies and nerve fibers in the brain which, together with physiological and electrophysiological studies, provide a better understanding of NPY neural circuitries. Expand
NPY Y1 and Y5 receptor selective antagonists as anti-obesity drugs.
  • D. Macneil
  • Medicine
  • Current topics in medicinal chemistry
  • 2007
A combination of pharmacological and genetic studies in mice confirmed that the Y1 and Y5 receptors mediate the potent orexigenic actions of exogenous NPY. Although the physiological role of NPY inExpand