Neuropeptide Y (NPY) cleaving enzymes: Structural and functional homologues of dipeptidyl peptidase 4

@article{Frerker2007NeuropeptideY,
  title={Neuropeptide Y (NPY) cleaving enzymes: Structural and functional homologues of dipeptidyl peptidase 4},
  author={Nadine Frerker and Leona Wagner and Raik Wolf and Ulrich Heiser and Torsten Hoffmann and Jens-Ulrich Rahfeld and Jutta Schade and Tim Karl and Hassan Y Naim and Marwan Alfalah and Hans-Ulrich Demuth and Stephan von H{\"o}rsten},
  journal={Peptides},
  year={2007},
  volume={28},
  pages={257-268}
}
N-terminal truncation of NPY has important physiological consequences, because the truncated peptides lose their capability to activate the Y1-receptor. The sources of N-terminally truncated NPY and related peptides are unknown and several proline specific peptidases may be involved. First, we therefore provide an overview on the peptidases, belonging to structural and functional homologues of dipeptidyl peptidase 4 (DP4) as well as aminopeptidase P (APP) and thus, represent potential… CONTINUE READING
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