Neuropeptide Y: Cerebrovascular innervation an vasomotor effects in the cat

  title={Neuropeptide Y: Cerebrovascular innervation an vasomotor effects in the cat},
  author={Lars Edvinsson and Piers C. Emson and J Mcculloch and Kazuhiko Tatemoto and Rolf Uddman},
  journal={Neuroscience Letters},
Avian pancreatic polypeptide (APP) has been proposed to be a neurotransmitter in a subpopulation of sympathetic nerves. Here, we present immunocytochemical and pharmacological evidence that the structurally related peptide, neuropeptide Y (NPY), is likely to be the biologically active material in these nerves. Cerebral arteries from cats are invested with a dense network of NPY-containing nerve fibres, as demonstrated by immunocytochemistry. This immunoreaction is abolished by prior removal of… CONTINUE READING
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