To our knowledge appetite-associated effects of neuropeptide SF (NPSF) are unreported. Thus chicks were intracerebroventricularly injected with 3.8, 7.5 and 15.0 nmol of NPSF and they reduced both their food and water intake. Blood glucose concentration was not affected. Additionally, NPSF-treated chicks did not exhibit any behaviors that were associated with stress or that may be competitive with ingestion. We conclude that NPSF is associated with anorectic and antidipsogenic effects.