Neuropeptide-S evoked arousal with electroencephalogram slow-wave compensatory drive in rats.

@article{Ahnaou2012NeuropeptideSEA,
  title={Neuropeptide-S evoked arousal with electroencephalogram slow-wave compensatory drive in rats.},
  author={Abdellah Ahnaou and Wilhelmus H.I.M. Drinkenburg},
  journal={Neuropsychobiology},
  year={2012},
  volume={65 4},
  pages={195-205}
}
OBJECTIVES Neuropeptide S (NPS) exerts a dual arousal and anxiolytic effect in rodents, which may indicate the potential of a novel class of therapeutic agents in psychiatry. The purpose of this study is to fully describe the nature of electroencephalogram (EEG)-defined waking that mediates these arousal effects. METHODS Effects of the intracerebroventricular infusion of NPS at 2 different doses were characterized over 20 h on sleep-wake architecture and EEG spectral components in rats that… CONTINUE READING

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