Neuropeptide S attenuates neuropathological, neurochemical and behavioral changes induced by the NMDA receptor antagonist MK-801.

@article{Okamura2010NeuropeptideSA,
  title={Neuropeptide S attenuates neuropathological, neurochemical and behavioral changes induced by the NMDA receptor antagonist MK-801.},
  author={Naoe Okamura and Rainer K Reinscheid and Shintaro Ohgake and Masaomi Iyo and Kenji Hashimoto},
  journal={Neuropharmacology},
  year={2010},
  volume={58 1},
  pages={166-72}
}
Neuropeptide S (NPS) and its cognate receptor were reported to mediate anxiolytic-like and arousal effects. NPS receptors are predominantly expressed in the brain, especially in limbic structures, including amygdala, olfactory nucleus, subiculum and retrosplenial cortex. In contrast, the NPS precursor is expressed in only a few brainstem nuclei where it is co-expressed with various excitatory transmitters, including glutamate. The current study investigates interactions of the NPS system with… CONTINUE READING