Neuropeptide S as a novel arousal promoting peptide transmitter.

  title={Neuropeptide S as a novel arousal promoting peptide transmitter.},
  author={Rainer K Reinscheid and Yan-ling Xu},
  journal={The FEBS journal},
  volume={272 22},
Behavioral arousal requires integration of multiple neurotransmitter and neuromodulatory systems. Identifying these systems is the key to not only a better understanding of the neurobiology of sleep/wakefulness but may also lead to the discovery of potential therapeutic targets for various sleep disorders. We review here a novel arousal promoting neuropeptide system, neuropeptide S (NPS) and its receptor. Pharmacologically, NPS activates NPS receptors at low nanomolar concentration to increase… CONTINUE READING