Neuropeptide Exocytosis Involving Synaptotagmin-4 and Oxytocin in Hypothalamic Programming of Body Weight and Energy Balance

@article{Zhang2011NeuropeptideEI,
  title={Neuropeptide Exocytosis Involving Synaptotagmin-4 and Oxytocin in Hypothalamic Programming of Body Weight and Energy Balance},
  author={Guo Yong Zhang and Hua Bai and Hai Zhang and Camin Dean and Qiang Wu and Juxue Li and Sara Rose Guariglia and Qingyuan Meng and Dongsheng Cai},
  journal={Neuron},
  year={2011},
  volume={69},
  pages={523-535}
}
Hypothalamic neuropeptides play essential roles in regulating energy and body weight balance. Energy imbalance and obesity have been linked to hypothalamic signaling defects in regulating neuropeptide genes; however, it is unknown whether dysregulation of neuropeptide exocytosis could be critically involved. This study discovered that synaptotagmin-4, an atypical modulator of synaptic exocytosis, is expressed most abundantly in oxytocin neurons of the hypothalamus. Synaptotagmin-4 negatively… CONTINUE READING
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