Neuropeptide Delivery to Synapses by Long-Range Vesicle Circulation and Sporadic Capture

@article{Wong2012NeuropeptideDT,
  title={Neuropeptide Delivery to Synapses by Long-Range Vesicle Circulation and Sporadic Capture},
  author={Man Yan Wong and Chaoming Zhou and Dinara Shakiryanova and Thomas E. Lloyd and David L Deitcher and Edwin S Levitan},
  journal={Cell},
  year={2012},
  volume={148},
  pages={1029-1038}
}
Neurotransmission requires anterograde axonal transport of dense core vesicles (DCVs) containing neuropeptides and active zone components from the soma to nerve terminals. However, it is puzzling how one-way traffic could uniformly supply sequential release sites called en passant boutons. Here, Drosophila neuropeptide-containing DCVs are tracked in vivo for minutes with a new method called simultaneous photobleaching and imaging (SPAIM). Surprisingly, anterograde DCVs typically bypass proximal… CONTINUE READING
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