Neuropeptide Y stimulates neuronal precursor proliferation in the post‐natal and adult dentate gyrus

@article{Howell2005NeuropeptideYS,
  title={Neuropeptide Y stimulates neuronal precursor proliferation in the post‐natal and adult dentate gyrus},
  author={Owain W. Howell and Kharen L. Doyle and Jeffrey H. Goodman and Helen E. Scharfman and Herbert Herzog and Ashley K. Pringle and Annette G. Beck‐Sickinger and William Peter Gray},
  journal={Journal of Neurochemistry},
  year={2005},
  volume={93}
}
Adult dentate neurogenesis is important for certain types of hippocampal‐dependent learning and also appears to be important for the maintenance of normal mood and the behavioural effects of antidepressants. Neuropeptide Y (NPY), a peptide neurotransmitter released by interneurons in the dentate gyrus, has important effects on mood, anxiety‐related behaviour and learning and memory. We report that adult NPY receptor knock‐out mice have significantly reduced cell proliferation and significantly… Expand
Exogenous neuropeptide Y promotes in vivo hippocampal neurogenesis
TLDR
It is shown that intracerebroventricular administration of NPY increases DG cell proliferation and promotes neuronal differentiation in C57BL/6 adult mice, demonstrating that NPY regulates in vivo hippocampal neurogenesis. Expand
Neuropeptide Y Promotes Neurogenesis in Murine Subventricular Zone
TLDR
NPY, as a promoter of SVZ neurogenesis, is a crucial factor for future development of cell‐based brain therapy and may be useful for the stimulation of SVz dynamic in brain repair purposes. Expand
Neuropeptide Y stimulates proliferation, migration and differentiation of neural precursors from the subventricular zone in adult mice
TLDR
It is demonstrated that intracerebroventricular injection of NPY stimulates proliferation of neural precursors in the mice subventricular zone (SVZ), one the most neurogenic areas of the brain. Expand
Neuropeptide Y in the dentate gyrus.
TLDR
Elevated expression of NPY in mossy fibers of the rat, sprouting ofNPY interneurons in the human dentate, and over-expression of Y2 receptors in mossY fibers indicate an anticonvulsive role of endogenousNPY in epilepsy, but the physiological role of NPy in the healthy dentate gyrus remains unclear. Expand
Neuropeptides and hippocampal neurogenesis
TLDR
Neuropeptides such as neuropeptide Y, vasoactive intestinal peptide (VIP) and galanin have emerged as important mediators for signalling local and extrinsic interneuronal activity to subgranular zone precursors and their precise effects on hippocampal neurogenesis are discussed. Expand
Neuropeptide Y stimulates retinal neural cell proliferation – involvement of nitric oxide
TLDR
NPY stimulates retinal neural cell proliferation, and this effect is mediated through nitric oxide–cyclic GMP and ERK 1/2 pathways. Expand
Intracellular Nitric Oxide Mediates Neuroproliferative Effect of Neuropeptide Y on Postnatal Hippocampal Precursor Cells*
TLDR
It is shown that NPY-mediated intracellular NO signaling results in an increase in neuroproliferation, and the importance of the NO-cGMP-PKG signaling pathway in ERK1/2 activation was confirmed using Western blotting. Expand
Microglial VPAC1R mediates a novel mechanism of neuroimmune-modulation of hippocampal precursor cells via IL-4 release
TLDR
It is shown that depleting microglia from hippocampal cultures reduces NSPC survival and proliferation, and demonstrates a potential neuro‐immuno‐neurogenic pathway, disruption of which may have significant implications in conditions where combined cognitive impairments, interneuron loss, and immune system activation occurs, such as temporal lobe epilepsy and Alzheimer's disease. Expand
Neuropeptide Y is important for basal and seizure-induced precursor cell proliferation in the hippocampus
TLDR
It is shown that neuropeptide Y regulates neurogenesis in the normal dentate gyrus (DG) via Y(1) receptors, and a proliferative effect of NPY on multipotent nestin cells expressing the stem cell marker Lewis-X from both the DG and the cSVZ/SCZ in vitro is shown. Expand
The Neurotransmitter VIP Expands the Pool of Symmetrically Dividing Postnatal Dentate Gyrus Precursors via VPAC2 Receptors or Directs Them Toward a Neuronal Fate via VPAC1 receptors
TLDR
This work provides the first evidence of differential fate modulation of neurogenesis by neurotransmitter receptor subtypes and extends the fate‐determining effects of neurotransmitters to maintaining the nestin‐positive pool of NSPCs. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 82 REFERENCES
Neuropeptide Y is neuroproliferative for post‐natal hippocampal precursor cells
TLDR
It is suggested that the proliferation of hippocampal neuroblasts and precursor cells is increased by neuropeptide Y and, therefore, that hippocampal learning and memory may be modulated by neuropezide Y‐releasing interneurones. Expand
Effects of adult neurogenesis on synaptic plasticity in the rat dentate gyrus.
TLDR
It is concluded that the young, adult-generated granule neurons play a significant role in synaptic plasticity in the DG, the major source of the afferent inputs into the hippocampus. Expand
Enhancement of Hippocampal Neurogenesis by Lithium
TLDR
The results add to the growing body of evidence suggesting that mood stabilizers and antidepressants exert neurotrophic effects and may therefore be of use in the long‐term treatment of other neuropsychiatric disorders. Expand
Neurogenesis in the Dentate Gyrus of the Adult Tree Shrew Is Regulated by Psychosocial Stress and NMDA Receptor Activation
TLDR
Results indicate that adult neurogenesis occurs in the tree shrew dentate gyrus and is regulated by a stressful experience and NMDA receptor activation, and it is suggested that these characteristics may be common to most mammalian species. Expand
Neuropeptide Y functions as a neuroproliferative factor
TLDR
The ability of NPY to induce neuronal precursor proliferation is mediated by protein kinase C (PKC), indicating an upstream PKC-dependent activation of ERK1/2. Expand
Neurogenesis in the adult is involved in the formation of trace memories
TLDR
It is shown that a substantial reduction in the number of newly generated neurons in the adult rat impairs hippocampal-dependent trace conditioning, a task in which an animal must associate stimuli that are separated in time. Expand
Regulation of adult neurogenesis by excitatory input and NMDA receptor activation in the dentate gyrus
  • H. Cameron, B. Mcewen, E. Gould
  • Chemistry, Medicine
  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1995
TLDR
The results suggest that adult neurogenesis in the dentate gyrus of the rat is altered by afferent input, via NMDA receptors, and may be regulated naturally by endogenous excitatory amino acids. Expand
Opioid-induced proliferation through the MAPK pathway in cultures of adult hippocampal progenitors
TLDR
A role for the opioid system is suggested in the regulation of proliferation in progenitors from the adult hippocampus through mediated through phosphorylation of extracellular signal-regulated kinases 1 and 2 and dependent on phosphatidylinositol 3-kinase and both intra- andextracellular calcium. Expand
Chronic Antidepressant Treatment Increases Neurogenesis in Adult Rat Hippocampus
TLDR
Investigation of the effect of antidepressants on hippocampal neurogenesis in the adult rat using the thymidine analog bromodeoxyuridine (BrdU) as a marker for dividing cells demonstrates that chronic antidepressant treatment significantly increases the number of BrdU-labeled cells in the dentate gyrus and hilus of the hippocampus. Expand
Mitotically active cells that generate neurons and astrocytes are present in multiple regions of the adult mouse hippocampus
TLDR
The results demonstrate that the phenomenon is not limited to the region of the dentate gyrus, but rather extends into Ammon's horn, and suggests that ongoing cell production, albeit discrete and limited in nature, may be widespread in the adult mammalian central nervous system. Expand
...
1
2
3
4
5
...