Neuropeptidase activity is down-regulated by estradiol in steroid-sensitive regions of the hypothalamus in female mice.

Abstract

Thimet oligopeptidase (TOP) and prolyl endopeptidase (PEP) are neuropeptidases involved in the hydrolysis of gonadotropin-releasing hormone, a key component of the hypothalamic-pituitary-gonadal axis. GnRH is regulated in part by feedback from steroid hormones such as estradiol. Previously, we demonstrated that TOP levels are down-regulated by estradiol in… (More)
DOI: 10.1016/j.npep.2012.04.002

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Cite this paper

@article{Bruce2012NeuropeptidaseAI, title={Neuropeptidase activity is down-regulated by estradiol in steroid-sensitive regions of the hypothalamus in female mice.}, author={Lisa A Bruce and Nicole E. Cyr and Jana W. Qiao and Christa C Defries and Marc J Tetel and Adele J. Wolfson}, journal={Neuropeptides}, year={2012}, volume={46 4}, pages={167-72} }