Neuropathy target esterase and a homologous Drosophila neurodegeneration-associated mutant protein contain a novel domain conserved from bacteria to man.

@article{Lush1998NeuropathyTE,
  title={Neuropathy target esterase and a homologous Drosophila neurodegeneration-associated mutant protein contain a novel domain conserved from bacteria to man.},
  author={Michael J. Lush and Yaw-Kuen Li and David J. Read and Antony C. Willis and P. T. Glynn},
  journal={The Biochemical journal},
  year={1998},
  volume={332 ( Pt 1)},
  pages={1-4}
}
The N-terminal amino acid sequences of proteolytic fragments of neuropathy target esterase (NTE), covalently labelled on its active-site serine by a biotinylated organophosphorus ester, were determined and used to deduce the location of this serine residue and to initiate cloning of its cDNA. A putative NTE clone, isolated from a human foetal brain cDNA library, encoded a 1327 residue polypeptide with no homology to any known serine esterases or proteases. The active-site serine of NTE (Ser-966… CONTINUE READING

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