Neuropathology of remote hypoxic-ischemic damage in the immature rat

  title={Neuropathology of remote hypoxic-ischemic damage in the immature rat},
  author={Javad Towfighi and Jerome Yale Yager and Cathy Housman and Robert C. Vannucci},
  journal={Acta Neuropathologica},
This study was undertaken to determine: (a) the duration of hypoxia required to produce brain damage in immature rats with unilateral carotid artery ligation (Levine technique); (b) the regions of immature brain most vulnerable to hypoxia-ischemia (HI); and (c) the neuropathology of the remote HI insult. To this end, 7-day postnatal rats, subjected to unilateral carotid artery ligation combined with hypoxia of varying durations (45, 60, 75 or 90 min), were killed at 30 days of postnatal age and… CONTINUE READING


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