Neuropathology of nondemented aging: presumptive evidence for preclinical Alzheimer disease.

  title={Neuropathology of nondemented aging: presumptive evidence for preclinical Alzheimer disease.},
  author={Joseph L. Price and D Mckeel and Virginia Buckles and Catherine M. Roe and Chengjie Xiong and Michael Grundman and Lawrence Arthur Hansen and Ronald C. Petersen and Joseph E. Parisi and Dennis W. Dickson and Charles D. Smith and Daron G. Davis and Frederick A. Schmitt and William R. Markesbery and Jeffrey Kaye and Roger M. Kurlan and Christine Hulette and Brenda F. Kurland and Roger Higdon and Walter B Kukull and John C. Morris},
  journal={Neurobiology of aging},
  volume={30 7},
OBJECTIVE To determine the frequency and possible cognitive effect of histological Alzheimer's disease (AD) in autopsied older nondemented individuals. DESIGN Senile plaques (SPs) and neurofibrillary tangles (NFTs) were assessed quantitatively in 97 cases from 7 Alzheimer's Disease Centers (ADCs). Neuropathological diagnoses of AD (npAD) were also made with four sets of criteria. Adjusted linear mixed models tested differences between participants with and without npAD on the quantitative… CONTINUE READING
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