Neuropathology of non-motor features of Parkinson disease.

  title={Neuropathology of non-motor features of Parkinson disease.},
  author={Dennis W. Dickson and Hiroshige Fujishiro and Carolyn F. Orr and Anthony Delledonne and Keith A. Josephs and Roberta Frigerio and Melinda S Burnett and Joseph E. Parisi and Kevin J. Klos and J. Eric Ahlskog},
  journal={Parkinsonism & related disorders},
  volume={15 Suppl 3},
Non-motor manifestations of Parkinson disease (PD) are common and some may actually antedate motor dysfunction. Extrapyramidal signs in PD are tightly linked to striatonigral dopaminergic denervation associated with neuronal loss and Lewy bodies in the residual neurons of the substantia nigra. Lewy bodies composed of abnormal alpha-synuclein are the histologic hallmark of PD, and their presence beyond midbrain dopaminergic neurons is considered to be the pathologic substrate of many, if not all… CONTINUE READING


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