Neuropathology of mitochondrial diseases

@article{Filosto2007NeuropathologyOM,
  title={Neuropathology of mitochondrial diseases},
  author={Massimiliano Filosto and Giuliano Tomelleri and Paola Tonin and Mauro Scarpelli and Gaetano Vattemi and Nicolo’ Rizzuto and Alessandro Padovani and Alessandro Simonati},
  journal={Bioscience Reports},
  year={2007},
  volume={27},
  pages={23-30}
}
The term “mitochondrial diseases” (MD) refers to a group of disorders related to respiratory chain dysfunction. Clinical features are usually extremely heterogeneous because MD may involve several tissues with different degrees of severity. Muscle and brain are mostly affected, probably because of their high dependence on oxidative metabolism.Muscle can be the only affected tissue or involved as a part of a multi-system disease; ragged red fibers, accumulation of structurally altered… 
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