Neuropathology of HTLV-I-associated myelopathy--a report of two autopsy cases.

  title={Neuropathology of HTLV-I-associated myelopathy--a report of two autopsy cases.},
  author={Shuji Izumo and Toshiharu Ijichi and Itsuro Higuchi and Akimasa Tashiro and Keiichi Takahashi and Mitsuhiro Osame},
  journal={Acta paediatrica Japonica : Overseas edition},
  volume={34 3},
A neuropathological analysis was performed in two autopsy cases of HTLV-I-associated myelopathy. The thoracic spinal cords were most severely affected and the histopathological findings consisted of mononuclear cell infiltration, marked destruction of myelin and axons and astrocytic gliosis. More than half the infiltrated cells were positive for pan-T cell marker; B cells were sparse in the parenchyma and subarachnoid spaces. CD4 and CD8 positive cells were found in the early stages of the… CONTINUE READING


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