Neuropathology of HTLV-1-associated myelopathy (HAM/TSP).

  title={Neuropathology of HTLV-1-associated myelopathy (HAM/TSP).},
  author={Shuji Izumo and Fujio Umehara and Nobuyuki Kashio and Ryuji Kubota and Eiichi Sato and Mitsuhiro Osame},
  volume={11 Suppl 3},
In order to clarify pathogenesis of HAM/TSP, we performed a detailed neuropathologic analysis of seven autopsy patients with HAM/TSP. Inflammatory infiltrates of mononuclear cells and degeneration of myelin and axons were noted in the middle to lower thoracic spinal cords and were continuously extended to the entire spinal cord. Horizontal distribution of inflammatory lesions was symmetric at any spinal levels. Immunohistochemical analysis demonstrated T-cell dominance. The numbers of CD4+ T… CONTINUE READING


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