Neuropathology of Frontotemporal Lobar Degeneration-Tau (FTLD-Tau)

  title={Neuropathology of Frontotemporal Lobar Degeneration-Tau (FTLD-Tau)},
  author={Dennis W. Dickson and Naomi Kouri and Melissa E. Murray and Keith A. Josephs},
  journal={Journal of Molecular Neuroscience},
A clinically and pathologically heterogeneous type of frontotemporal lobar degeneration has abnormal tau pathology in neurons and glia (FTLD-tau). Familial FTLD-tau is usually due to mutations in the tau gene (MAPT). Even FTLD-tau determined by MAPT mutations has clinical and pathologic heterogeneity. Tauopathies are subclassified according to the predominant species of tau that accumulates, with respect to alternative splicing of MAPT, with tau proteins containing three (3R) or four repeats… CONTINUE READING
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