Neuropathology of Down syndrome and Alzheimer disease.

  title={Neuropathology of Down syndrome and Alzheimer disease.},
  author={Linda Collins Cork},
  journal={American journal of medical genetics. Supplement},
Patients with Down syndrome (DS) over 40 years of age, prematurely and consistently develop neurofibrillary tangles (NFT), intracytoplasmic inclusions of highly insoluble straight or paired helical 12-16 nm filaments, and senile plaques (SP) composed of abnormal neurites surrounding a core of beta amyloid. These two lesions occur in distributions similar to those seen in Alzheimer disease (AD). SP and NFT are detected also in some younger individuals with DS (10-30+ years) when… CONTINUE READING


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