Neuropathology in mice expressing human alpha-synuclein.

  title={Neuropathology in mice expressing human alpha-synuclein.},
  author={Herman van der Putten and K. H. Wiederhold and Alphonse Probst and Samuel Barbieri and Claudia Mistl and Simone Danner and Sabine Kauffmann and Katja Hofele and Will P. J. M. Spooren and Markus A. Ruegg and Shuo Lin and Pico Caroni and Bernd Sommer and Markus Tolnay and Graeme Bilbe},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={20 16},
The presynaptic protein alpha-synuclein is a prime suspect for contributing to Lewy pathology and clinical aspects of diseases, including Parkinson's disease, dementia with Lewy bodies, and a Lewy body variant of Alzheimer's disease. alpha-Synuclein accumulates in Lewy bodies and Lewy neurites, and two missense mutations (A53T and A30P) in the alpha-synuclein gene are genetically linked to rare familial forms of Parkinson's disease. Under control of mouse Thy1 regulatory sequences, expression… CONTINUE READING


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