Neuropathology and biochemistry of Aβ and its aggregates in Alzheimer’s disease

  title={Neuropathology and biochemistry of Aβ and its aggregates in Alzheimer’s disease},
  author={Dietmar Rudolf Thal and Jochen Walter and Takaomi C Saido and Marcus F{\"a}ndrich},
  journal={Acta Neuropathologica},
Alzheimer’s disease (AD) is characterized by β-amyloid plaques and intraneuronal τ aggregation usually associated with cerebral amyloid angiopathy (CAA). Both β-amyloid plaques and CAA deposits contain fibrillar aggregates of the amyloid β-peptide (Aβ). Aβ plaques and CAA develop first in neocortical areas of preclinical AD patients and, then, expand in a characteristic sequence into further brain regions with end-stage pathology in symptomatic AD patients. Aβ aggregates are not restricted to… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 4 times over the past 90 days. VIEW TWEETS
33 Citations
154 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 33 extracted citations


Publications referenced by this paper.
Showing 1-10 of 154 references

initial report of the purification and characterization of a novel cerebrovascular amyloid protein

  • GG Glenner, Wong CW Alzheimer’s disease
  • Biochem Biophys Res Commun 120:885–890 179 Acta…
  • 2015
Highly Influential
18 Excerpts

The presence of sodium dodecyl sulphate-stable Abeta dimers is strongly associated with Alzheimer-type dementia

  • JM Mc Donald, GM Savva, +6 authors DM Walsh
  • Brain
  • 2010
Highly Influential
4 Excerpts

The pathogenesis of senile plaques

  • DW Dickson
  • J Neuropathol Exp Neurol
  • 1997
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…