Neuropathology and biochemistry of Aβ and its aggregates in Alzheimer’s disease

@article{Thal2014NeuropathologyAB,
  title={Neuropathology and biochemistry of Aβ and its aggregates in Alzheimer’s disease},
  author={Dietmar Rudolf Thal and Jochen Walter and Takaomi C Saido and Marcus F{\"a}ndrich},
  journal={Acta Neuropathologica},
  year={2014},
  volume={129},
  pages={167-182}
}
Alzheimer’s disease (AD) is characterized by β-amyloid plaques and intraneuronal τ aggregation usually associated with cerebral amyloid angiopathy (CAA). Both β-amyloid plaques and CAA deposits contain fibrillar aggregates of the amyloid β-peptide (Aβ). Aβ plaques and CAA develop first in neocortical areas of preclinical AD patients and, then, expand in a characteristic sequence into further brain regions with end-stage pathology in symptomatic AD patients. Aβ aggregates are not restricted to… CONTINUE READING
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