Neuropathological substrates of dementia and depression in vascular dementia, with a particular focus on cases with small infarct volumes.

@article{Ballard2000NeuropathologicalSO,
  title={Neuropathological substrates of dementia and depression in vascular dementia, with a particular focus on cases with small infarct volumes.},
  author={Clive G. Ballard and Ian G. McKeith and John T. O'Brien and R. I. Kalaria and Evelyn Jaros and Paul G. Ince and Robert H. Perry},
  journal={Dementia and geriatric cognitive disorders},
  year={2000},
  volume={11 2},
  pages={59-65}
}
The neuropathological substrates of dementia and depression were evaluated in 30 patients with cerebrovascular disease and significant cognitive impairment (VaD), with a particular focus on patients with small infarct volumes (<15 ml). VaD patients with small infarct volumes had a similar degree of cognitive impairment to those with larger infarct volumes (>15 ml) but were significantly more likely to be depressed and to have areas of microinfarction. A review of individual cases with small… CONTINUE READING