Neuropathological studies of synaptic connectivity in the hippocampal formation in schizophrenia

@article{Harrison2001NeuropathologicalSO,
  title={Neuropathological studies of synaptic connectivity in the hippocampal formation in schizophrenia},
  author={Paul J. Harrison and Sharon L. Eastwood},
  journal={Hippocampus},
  year={2001},
  volume={11}
}
Cytoarchitectural changes in the hippocampal formation have been prominent among the various neuropathological abnormalities reported in schizophrenia. Replicated positive findings include decreased neuronal size and alterations in presynaptic and dendritic markers. These findings, in the absence of neurodegenerative changes, suggest that there are alterations in the neural circuitry in schizophrenia. These may represent the anatomical correlate of the aberrant functional connectivity described… 
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References

SHOWING 1-10 OF 141 REFERENCES
Cell biology of the hippocampal formation in schizophrenia
SNAP-25 deficit and hippocampal connectivity in schizophrenia.
TLDR
Results indicate that disconnection of a subset of hippocampal circuitry from the entorhinal cortex, as well as intrinsic changes in hippocampal connectivity, may contribute to the mechanism of illness in schizophrenia.
Schizophrenia as a disorder of developmentally reduced synaptic connectivity.
TLDR
A computer simulation of the elimination of the synaptic connections that models normal cognitive development and psychotic symptom formation is reviewed and some of the model's predictions and questions raised for basic research, early detection, and preventive intervention are discussed.
The hippocampus in schizophrenia: lateralized increase in neuronal density and altered cytoarchitectural asymmetry.
TLDR
The nature of the findings is consistent with a neurodevelopmental origin, and with a disease process that affects cerebral asymmetry and leaves its imprint upon the hippocampal cytoarchitecture.
The neuropathology of schizophrenia. A critical review of the data and their interpretation.
TLDR
Functional imaging data indicate that the pathophysiology of schizophrenia reflects aberrant activity in, and integration of, the components of distributed circuits involving the prefrontal cortex, hippocampus and certain subcortical structures.
The neuropsychology of schizophrenia
Abstract A model is proposed for integrating the neural and cognitive aspects of the positive symptoms of acute schizophrenia, using evidence from postmortem neuropathology and neurochemistry,
...
1
2
3
4
5
...