Neuropathological stageing of Alzheimer-related changes

@article{Braak2004NeuropathologicalSO,
  title={Neuropathological stageing of Alzheimer-related changes},
  author={Heiko Braak and E. van Braak},
  journal={Acta Neuropathologica},
  year={2004},
  volume={82},
  pages={239-259}
}
SummaryEighty-three brains obtained at autopsy from nondemented and demented individuals were examined for extracellular amyloid deposits and intraneuronal neurofibrillary changes. The distribution pattern and packing density of amyloid deposits turned out to be of limited significance for differentiation of neuropathological stages. Neurofibrillary changes occurred in the form of neuritic plaques, neurofibrillary tangles and neuropil threads. The distribution of neuritic plaques varied widely… 
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