Neuropathological examination suggests impaired brain iron acquisition in restless legs syndrome

  title={Neuropathological examination suggests impaired brain iron acquisition in restless legs syndrome},
  author={James R. Connor and Philip J. Boyer and Sharon L. Menzies and Bart Dellinger and Richard P. Allen and William G Ondo and Christopher J. Earley},
  pages={304 - 309}
Objective: To assess neuropathology in individuals with restless legs syndrome (RLS). Methods: A standard neuropathologic evaluation was performed on seven brains from individuals who had been diagnosed with RLS. The substantia nigra was examined in greater detail for iron staining and with immunohistochemistry for tyrosine hydroxylase and proteins involved in iron management. Five age-matched individuals with no neurologic history served as controls. Results: There were no histopathologic… 

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