Neuropathological effects of phenyl saligenin phosphate in chickens.

@article{Jortner1987NeuropathologicalEO,
  title={Neuropathological effects of phenyl saligenin phosphate in chickens.},
  author={Bernard S. Jortner and Marion F Ehrich},
  journal={Neurotoxicology},
  year={1987},
  volume={8 2},
  pages={303-14}
}
Cyclic phenyl saligenin phosphate (PSP) proved to be a potent delayed neurotoxin, eliciting clinical disease and lesions, and depressing neuropathy target esterase and plasma cholinesterase at much lower doses than the protoxicant tri-ortho-tolyl phosphate (TOTP). Using adult White Leghorn chickens, we noted qualitative similarities in clinical signs and peripheral nerve and spinal cord lesions elicited by PSP and the TOTP. Ataxia and weakness were prominent clinical effects. Lesions began as a… CONTINUE READING
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