Neuropathogenesis of a mouse-adapted porcine epidemic diarrhea virus infection in suckling mice.

@article{Kotani2013NeuropathogenesisOA,
  title={Neuropathogenesis of a mouse-adapted porcine epidemic diarrhea virus infection in suckling mice.},
  author={Osamu Kotani and Kazuya Shirato and Noriyo Nagata and Hidetoshi Ikeda and Kimimasa Takahashi and Fumihiro Taguchi},
  journal={The Journal of general virology},
  year={2013},
  volume={94 Pt 4},
  pages={
          831-6
        }
}
  • Osamu Kotani, Kazuya Shirato, +3 authors Fumihiro Taguchi
  • Published in
    The Journal of general…
    2013
  • Biology, Medicine
  • A mouse-adapted porcine epidemic diarrhea virus, MK-p10, showed higher neurovirulence in suckling mice than a non-adapted MK strain. There was no difference in virus growth, whereas clear differences between these two virus infections existed in the type of target cells infected, the spread of virus and the cytokine levels produced in the brain. In the early phase of infection, neurons, astrocytes and neural progenitor cells were infected by MK-p10, whereas neural progenitor cells were the only… CONTINUE READING

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